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Fluconazole (Diflucan) and Alcohol Interaction: Can You Drink Alcohol with Fluconazole?


Author: Thomas Roth

Last Updated: 3/28/2022

Fluconazole is an antifungal drug, specifically an azole antifungal, that is used to prevent and treat fungal infections, such as yeast infections. It is available in tablet and liquid forms and should be taken with food, usually once a day.

An azole antifungal works by stopping the growth of certain types of fungus that cause infections and works best when there is a consistent amount of the medication in your system over some time. The most common dosage of fluconazole for adults starts with 200 mg the first day, followed by 100mg on subsequent days for at least three weeks. However, for more serious infections the dosage can be closer to 400mg on the first day, with 200mg being taken every subsequent day for the next 10-12 weeks.

What are the Effects of Mixing Alcohol and Fluconazole?

Some of the most common side effects of Fluconazole include.

  • Nausea
  • Vomiting
  • Diarrhea
  • Upset stomach or stomach pain
  • Headache
  • Dizziness
  • Hair Loss

More serious side effects include.

  • Loss of appetite
  • Unusual tiredness
  • Weight Loss

These three symptoms, especially when experienced together, can be indications that your adrenal glands are not functioning properly.

Some of the most serious side effects are.

  • Fast or irregular heartbeat
  • Severe dizziness
  • Fainting
  • Liver Disease

Symptoms such as nausea, vomiting, diarrhea, and dizziness are also side effects of alcohol consumption and it can be difficult to differentiate which drug is causing these side effects. Additionally, with symptoms such as severe dizziness, or an impaired state, it may make it difficult to determine the severity of the side effect, making you less likely to seek help. If you are experiencing any side effects, make sure to contact your health care professional or emergency services.

Does Fluconazole (Diflucan) Affect the Taste of Alcohol?

There is no evidence to suggest that Fluconazole affects the taste of alcohol. While drinking alcohol within seconds of taking fluconazole may impact the taste, it doesn’t for long periods. This can vary from person to person.

Can a mixture of Alcohol and Fluconazole Lead to death?

Yes, there is a chance that alcohol and Fluconazole can lead to death. Fluconazole poses the chance for a very serious side effect called QT prolongation which affects the timing in which your heart muscles are contracting and relaxing to pump blood throughout your body. Signs of overdose may include hallucinations and mental or mood changes. Please seek emergency medical assistance if you are experiencing these symptoms.

Does Dosage of Fluconazole (Diflucan) Affect the Interaction with Alcohol?

The dosage of fluconazole should not affect its interaction with alcohol, as long as alcohol is being consumed in moderation. As Fluconazole’s dosage is primarily based on age, weight, and medical condition, you should still aim to adhere to the suggested guidelines regarding daily recommended alcohol intake to lower the chance of adverse side effects.

Who Should Not Take Alcohol and Fluconazole?

While there are no known interactions between alcohol and fluconazole, there are certain risk factors and groups that should proceed with a higher level of caution:

  • Those with allergies to azole antifungal drugs
  • History of liver or kidney disease
  • Heart problems or family history of heart problems (including, but not limited to sudden cardiac death and QT prolongation)
    • Those with low levels of potassium or magnesium are at an increased risk.
  • Those who are pregnant, intend to become pregnant or are breastfeeding.
    • There is evidence to suggest that fluconazole can harm an unborn baby, especially during the first three months of pregnancy. Additionally,y there is evidence that fluconazole can pass into the breastmilk but it is unlikely to cause harm. Additionally, drinking alcohol while pregnant can have serious, irreversible effects on the fetus including, but not limited to, Fetal Alcohol Syndrome (FAC) which can cause irreversible growth and developmental problems for the fetus.

Are all types of Alcohol Harmful with Fluconazole?

No, all types of alcohol are not inherently harmful with fluconazole as long as it is used in moderation. The current recommendation regarding alcoholic drinks is 2 drinks a day for men and 1 drink a day for women. One alcoholic drink is defined as 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of liquor.

How Much Fluconazole can be Dangerous to Take with Alcohol?

Drinking alcohol in moderation should not be dangerous with fluconazole. The recommendation would be for no more than 1 drink a day for women and 2 drinks a day for men. Those who fit into an “at-risk” category should avoid alcohol while taking fluconazole due to the chance that it may make pre-existing conditions more severe, or you may experience more severe side effects. Additionally, if you are experiencing any abnormal side effects please talk to your health care provider or seek medical attention immediately.

Does Alcohol Affect How Well Fluconazole will Work?

No, alcohol does not necessarily affect how well fluconazole will work. However, mixing alcohol and fluconazole can lengthen the time it takes your body to heal, make you feel worse,e or amplify the side effects of the medication. Additionally, alcohol has been shown to cause yeast overgrowth. While fluconazole helps to treat many candida infections (such as yeast infections or thrush) drinking alcohol while on this medication has a chance to be counterproductive or even worsen the condition.

How Long After Taking Fluconazole Can You Drink Alcohol?

While there are no serious risks associated with drinking alcohol in moderation with fluconazole it is generally recommended that you wait 48 hours after your last dose to avoid the chance for serious interactions or side effects. This will also give the medication the highest chance for treatment success.

What are the Treatment Options for Fluconazole and Alcohol Abuse?

Some treatment options are:

  • Inpatient rehab facilities
    • These are live-in facilities that offer access to resources and support from medically trained professionals.
  • Outpatient rehab centers
    • These are centers that offer resources and support from medically trained professionals without the commitment to residency for some time. You are often expected to travel to the center from your home for some time to receive treatment.
  • Detox programs
    • These programs have the aim to help you wean off of the substance you are abusing or addicted to in a slow but safe way.
  • Individual therapy
    • Individual therapy allows you to work one on one with a trained professional. These services often aim to help you figure out the underlying causes and triggers for your addiction or substance abuse problem, and can offer ways to help you avoid or manage them in the future.
  • Group Therapy
    • Group therapy offers many of the same benefits as individual therapy, but also offers the support, insight, and understanding of others who are or have been in similar addiction or substance abuse situations while being guided by a trained professional.

All of these treatment options aim to help you to safely wean off of the drug that you are abusing in a safe, and healthy way and many can help in offering insight into why you may have developed the addiction and ways to prevent similar types of abuse in the future. If you or someone you know is suffering from addiction or drug abuse problems, you should reach out to see what options are available or best for your situation.

What Are Other Drugs That Are Dangerous To Use With Alcohol?

While many drugs are dangerous to use with alcohol, some of the most dangerous are:

  • Benzodiazepines (Xanax)
  • Antihistamines (Benadryl)
  • Opiates
  • Antidepressants

Please keep in mind that these are only some of the most dangerous drugs to use with alcohol and that any drug has the potential to be dangerous with alcohol if used incorrectly or abused. If you are unsure of symptoms you are experiencing or the potential interactions between certain medications and alcohol, please speak to your health care provider.